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???? ??????? ???????? ???????. ??? ????????? ?? ???? ?? ???????? ???? ????? ?? ??????????????? ?? ??????? ?? ?? ???????Sildenafil is often a potent and selective inhibitor of cGMP-specific phosphodiesterase style 5 (PDE5), that is chargeable for degradation of cGMP during the corpus cavernosum. The molecular framework of sildenafil is comparable to